Differential Antagonism of Activin, Myostatin and Growth and Differentiation Factor 11 by Wild-Type and Mutant Follistatin

Follistatin binds and neutralizes members of the TGFβ superfamily including activin, myostatin, and growth and differentiation factor 11 (GDF11). Crystal structure analysis of the follistatin-activin complex revealed extensive contacts between follistatin domain (FSD)-2 and activin that was critical...

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Main Authors: Schneyer, Alan L., Sidis, Yisrael, Gulati, Anisha, Sun, Jie L., Keutmann, Henry, Krasney, Philip A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Endocrine Society 2008
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553374/
https://ncbi.nlm.nih.gov/pubmed/18535106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0259
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