Characterizing Complex Dynamics in the Transactivation Response Element Apical Loop and Motional Correlations with the Bulge by NMR, Molecular Dynamics, and Mutagenesis

The HIV-1 transactivation response element (TAR) RNA binds a variety of proteins and is a target for developing anti-HIV therapies. TAR has two primary binding sites: a UCU bulge and a CUGGGA apical loop. We used NMR residual dipolar couplings, carbon spin relaxation (R(1) and R(2)), and relaxation...

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Main Authors: Dethoff, Elizabeth A., Hansen, Alexandar L., Musselman, Catherine, Watt, Eric D., Andricioaei, Ioan, Al-Hashimi, Hashim M.
格式: Artigo
語言:Inglês
出版: The Biophysical Society 2008
主題:
Nucleic Acids
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553144/
https://ncbi.nlm.nih.gov/pubmed/18621815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.140285
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