Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study

We have identified an alternative pathway of tumorigenesis in sporadic colon cancer, involving microsatellite instability due to mismatched repair methylation, which may be driven by mutations in the BRAF gene (V600E). Colorectal cancer (CRC) is the most common cancer in the world, and African Ameri...

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Detalhes bibliográficos
Main Authors: Brim, Hassan, Mokarram, Pooneh, Naghibalhossaini, Fakhraddin, Saberi-Firoozi, Mehdi, Al-Mandhari, Mansour, Al-Mawaly, Kamla, Al-Mjeni, Rayhaneh, Al-Sayegh, Abeer, Raeburn, Sandy, Lee, Edward, Giardiello, Francis, Smoot, Duane T, Vilkin, Alexander, Boland, C Richard, Goel, Ajay, Hafezi, Mitra, Nouraie, Mehdi, Ashktorab, Hassan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2551625/
https://ncbi.nlm.nih.gov/pubmed/18718023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-7-68
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