Optimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: The effect of water and timing of meal intake on oral delivery of Salmon Calcitonin

BACKGROUND: To investigate the influence of water intake and dose timing on the pharmacokinetic and pharmacodynamic parameters of an oral formulation of salmon calcitonin (sCT). METHODS: The study was a randomized, partially-blind, placebo-controlled, single dose, exploratory crossover phase I study...

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Bibliographic Details
Main Authors: Karsdal, Morten A, Byrjalsen, Inger, Riis, Bente J, Christiansen, Claus
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2551583/
https://ncbi.nlm.nih.gov/pubmed/18782439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6904-8-5
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