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Site-specific incorporation of unnatural amino acids into urate oxidase in Escherichia coli
Urate oxidase catalyzes the oxidation of uric acid with poor solubility to produce 5-hydroxyisourate and allantoin. Since allantoin is excreted in vivo, urate oxidase has the potential to be a therapeutic target for the treatment of gout. However, its severe immunogenicity limits its clinical applic...
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| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Cold Spring Harbor Laboratory Press
2008
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2548377/ https://ncbi.nlm.nih.gov/pubmed/18596202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.034587.108 |
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