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Haplotype block partitioning as a tool for dimensionality reduction in SNP association studies

BACKGROUND: Identification of disease-related genes in association studies is challenged by the large number of SNPs typed. To address the dilution of power caused by high dimensionality, and to generate results that are biologically interpretable, it is critical to take into consideration spatial c...

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Detalhes bibliográficos
Main Authors: Pattaro, Cristian, Ruczinski, Ingo, Fallin, Danièle M, Parmigiani, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2547855/
https://ncbi.nlm.nih.gov/pubmed/18759977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-9-405
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