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Conformational Changes in the Selectivity Filter of the Open-State KcsA Channel: An Energy Minimization Study
Potassium channels switch between closed and open conformations and selectively conduct K(+) ions. There are at least two gates. The TM2 bundle at the intracellular site is the primary gate of KcsA, and rearrangements at the selectivity filter (SF) act as the second gate. The SF blocks ion flow via...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2547464/ https://ncbi.nlm.nih.gov/pubmed/18621821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.136556 |
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