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An Approach to the Total Synthesis of Welwistatin
An approach to the total synthesis of the anti-microtubule agent welwistatin is described. Key transformations include 1) a 7-endo intramolecular conjugate addition reaction of enone 6 to deliver the strained bicyclo[4.3.1]decanone 5; 2) a 6π electrocyclic ring closure of trienecarbamate 1 6 followe...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2547338/ https://ncbi.nlm.nih.gov/pubmed/16737334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol0608799 |
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