Generation and characterization of a human single-chain fragment variable (scFv) antibody against cytosine deaminase from Yeast

BACKGROUND: The ability of cytosine deaminase (CD) to convert the antifungal agent 5-fluorocytosine (5-FC) into one of the most potent and largely used anticancer compound such as 5-fluorouracil (5-FU) raised considerable interest in this enzyme to model gene or antibody – directed enzyme-prodrug th...

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Autors principals: Mallano, Alessandra, Zamboni, Silvia, Carpinelli, Giulia, Santoro, Filippo, Flego, Michela, Ascione, Alessandro, Gellini, Mara, Tombesi, Marina, Podo, Franca, Cianfriglia, Maurizio
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2008
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2547108/
https://ncbi.nlm.nih.gov/pubmed/18783590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-8-68
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