The Forkhead Transcription Factor FOXO3a Increases Phosphoinositide-3 Kinase/Akt Activity in Drug-Resistant Leukemic Cells through Induction of PIK3CA Expression

The phosphoinositide-3 kinase (PI3K)/Akt signal pathway plays a key role in the tumorigenesis of many cancers and in the subsequent development of drug resistance. Using the K562 chronic myelogenous leukemia (CML) cell line and the doxorubicin-resistant derivative lines KD30 and KD225 as models, we...

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Main Authors: Hui, Rosaline C.-Y., Gomes, Ana R., Constantinidou, Demetra, Costa, Joana R., Karadedou, Christina T., Fernandez de Mattos, Silvia, Wymann, Matthias P., Brosens, Jan J., Schulze, Almut, Lam, Eric W.-F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2547013/
https://ncbi.nlm.nih.gov/pubmed/18644865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01265-07
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