Inhibition of Human Immunodeficiency Virus Type 1 Assembly and Release by the Cholesterol-Binding Compound Amphotericin B Methyl Ester: Evidence for Vpu Dependence

We investigated the mechanism by which the cholesterol-binding compound amphotericin B methyl ester (AME) inhibits human immunodeficiency virus type 1 (HIV-1) particle production. We observed no significant effect of AME on Gag binding to the plasma membrane, Gag association with lipid rafts, or Gag...

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Hlavní autoři: Waheed, Abdul A., Ablan, Sherimay D., Soheilian, Ferri, Nagashima, Kunio, Ono, Akira, Schaffner, Carl P., Freed, Eric O.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Structure and Assembly
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546975/
https://ncbi.nlm.nih.gov/pubmed/18653459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00917-08
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