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Comparative Analysis of Nearly Full-Length Hepatitis C Virus Quasispecies from Patients Experiencing Viral Breakthrough during Antiviral Therapy: Clustered Mutations in Three Functional Genes, E2, NS2, and NS5a

Viral breakthrough is a recognized response pattern to interferon-based antiviral therapy in patients with chronic hepatitis C virus (HCV) infection. The emergence of drug-resistant HCV quasispecies variants is assumed to be a major mechanism responsible for viral breakthrough. By using a long rever...

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מידע ביבליוגרפי
Main Authors: Xu, Zekuan, Fan, Xiaofeng, Xu, Yanjuan, Di Bisceglie, Adrian M.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546966/
https://ncbi.nlm.nih.gov/pubmed/18667493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00896-08
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