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Frequency and Spectrum of Genomic Integration of Recombinant Adeno-Associated Virus Serotype 8 Vector in Neonatal Mouse Liver

Neonatal injection of recombinant adeno-associated virus serotype 8 (rAAV8) vectors results in widespread transduction in multiple organs and therefore holds promise in neonatal gene therapy. On the other hand, insertional mutagenesis causing liver cancer has been implicated in rAAV-mediated neonata...

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Autori principali: Inagaki, Katsuya, Piao, Chuncheng, Kotchey, Nicole M., Wu, Xiaolin, Nakai, Hiroyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546949/
https://ncbi.nlm.nih.gov/pubmed/18614641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01001-08
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