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Proteolytic Shedding of ST6Gal-I by BACE1 Regulates the Glycosylation and Function of α4β1 Integrins

Differentiation of monocytes into macrophages is accompanied by increased cell adhesiveness, due in part to the activation of α4β1 integrins. Here we report that the sustained α4β1 activation associated with macrophage differentiation results from expression of β1 integrin subunits that lack α2–6-li...

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Autors principals: Woodard-Grice, Alencia V., McBrayer, Alexis C., Wakefield, John K., Zhuo, Ya, Bellis, Susan L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546544/
https://ncbi.nlm.nih.gov/pubmed/18650447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800836200
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