Mutations in the hemagglutinin receptor-binding site can change the biological properties of an influenza virus.

Avian influenza virus reassortants containing human influenza virus hemagglutinins do not replicate in ducks. Two mutations in the receptor-binding site of a human hemagglutinin at residues 226 and 228 allowed replication in ducks. The mutations resulted in a receptor-binding-site sequence identical...

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Bibliographic Details
Published in:J Virol
Main Authors: Naeve, C W, Hinshaw, V S, Webster, R G
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1984
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC254476/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6748165/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.51.2.567-569.1984
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