Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria

Infection of mice with sporozoites of Plasmodium berghei or Plasmodium yoelii has been used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria vaccines. Unfortunately, repeated success of such vaccines in mice has not translated readily to effective malaria vaccines...

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Main Authors: Schmidt, Nathan W., Podyminogin, Rebecca L., Butler, Noah S., Badovinac, Vladimir P., Tucker, Brad J., Bahjat, Keith S., Lauer, Peter, Reyes-Sandoval, Arturo, Hutchings, Claire L., Moore, Anne C., Gilbert, Sarah C., Hill, Adrian V., Bartholomay, Lyric C., Harty, John T.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544571/
https://ncbi.nlm.nih.gov/pubmed/18780790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805452105
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