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Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity

Plasmodium infections are responsible for millions of cases of malaria and about one million deaths annually. Recently, we showed that sterile protection (95%) in BALB/c mice required P. berghei circumsporozoite (CS(252-260))-specific memory CD8 T-cells exceeding a threshold of ≥1% of all PBL. Impor...

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Main Authors: Schmidt, Nathan W., Butler, Noah S., Harty, John T.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087867/
https://ncbi.nlm.nih.gov/pubmed/21460205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100194
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