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Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection
The induced fit and conformational selection/population shift models are two extreme cases of a continuum aimed at understanding the mechanism by which the final key-lock or active enzyme conformation is achieved upon formation of the correctly ligated enzyme. Structures of complexes representing th...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2544539/ https://ncbi.nlm.nih.gov/pubmed/18772387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805364105 |
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