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Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate-dependent endocytosis
How granzymes gain entry into the cytosol of target cells during killer cell attack has been the subject of several studies in the past, but the effective delivery mechanism during target cell encounter has not been clarified. Here we show that granzyme B (GzmB) mutants lacking binding to negatively...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2544534/ https://ncbi.nlm.nih.gov/pubmed/18772390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801724105 |
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