Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice

Pyruvate dehydrogenase complex (PDC) plays an important role in energy homeostasis in the heart by catalyzing the oxidative decarboxylation of pyruvate derived primarily from glucose and lactate. Because various pathophysiological states can markedly alter cardiac glucose metabolism and PDC has been...

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Bibliographic Details
Main Authors: Sidhu, Sukhdeep, Gangasani, Ashish, Korotchkina, Lioubov G., Suzuki, Gen, Fallavollita, James A., Canty, John M., Patel, Mulchand S.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544487/
https://ncbi.nlm.nih.gov/pubmed/18586888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00363.2008
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