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Chemotoxicity of doxorubicin and surface expression of P-glycoprotein (MDR1) is regulated by the Pseudomonas aeruginosa toxin Cif

P-glycoprotein (Pgp), a member of the adenosine triphosphate-binding cassette (ABC) transporter superfamily, is a major drug efflux pump expressed in normal tissues, and is overexpressed in many human cancers. Overexpression of Pgp results in reduced intracellular drug concentration and cytotoxicity...

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Detalhes bibliográficos
Main Authors: Ye, Siying, MacEachran, Daniel P., Hamilton, Joshua W., O'Toole, George A., Stanton, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544439/
https://ncbi.nlm.nih.gov/pubmed/18650266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00234.2008
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