Detection of a Point Mutation Associated with High-Level Isoniazid Resistance in Mycobacterium tuberculosis by Using Real-Time PCR Technology with 3′-Minor Groove Binder-DNA Probes

Tuberculosis remains one of the leading infectious causes of death worldwide. The emergence of drug-resistant strains of Mycobacterium tuberculosis is a serious public health threat. Resistance to isoniazid (INH) is the most prevalent form of resistance in M. tuberculosis and is mainly caused by mut...

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Detalhes bibliográficos
Main Authors: van Doorn, H. Rogier, Claas, Eric C. J., Templeton, Kate E., van der Zanden, Adri G. M., te Koppele Vije, Arianne, de Jong, Menno D., Dankert, Jacob, Kuijper, Ed J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mycobacteriology and Aerobic Actinomycetes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC254323/
https://ncbi.nlm.nih.gov/pubmed/14532194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.41.10.4630-4635.2003
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