Hypoxia Inducible Factor-1α Inactivation Unveils a Link between Tumor Cell Metabolism and Hypoxia-Induced Cell Death

Hypoxia and the acquisition of a glycolytic phenotype are intrinsic features of the tumor microenvironment. The hypoxia inducible factor-1α (HIF-1α) pathway is activated under hypoxic conditions and orchestrates a complex transcriptional program that enhances cell survival. Although the consequences...

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Main Authors: Favaro, Elena, Nardo, Giorgia, Persano, Luca, Masiero, Massimo, Moserle, Lidia, Zamarchi, Rita, Rossi, Elisabetta, Esposito, Giovanni, Plebani, Mario, Sattler, Ulrike, Mann, Thomas, Mueller-Klieser, Wolfgang, Ciminale, Vincenzo, Amadori, Alberto, Indraccolo, Stefano
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2008
Teme:
Regular Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2543085/
https://ncbi.nlm.nih.gov/pubmed/18772337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.071183
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