Smad-Independent Transforming Growth Factor-β Regulation of Early Growth Response-1 and Sustained Expression in Fibrosis : Implications for Scleroderma

Transforming growth factor-β (TGF-β) plays a key role in scleroderma pathogenesis. The transcription factor early growth response-1 (Egr-1) mediates the stimulation of collagen transcription elicited by TGF-β and is necessary for the development of pulmonary fibrosis in mice. Here, we report that TG...

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Main Authors: Bhattacharyya, Swati, Chen, Shu-Jen, Wu, Minghua, Warner-Blankenship, Matthew, Ning, Hongyan, Lakos, Gabriella, Mori, Yasuji, Chang, Eric, Nihijima, Chihiro, Takehara, Kazuhiro, Feghali-Bostwick, Carol, Varga, John
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2008
Teme:
Regular Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2543076/
https://ncbi.nlm.nih.gov/pubmed/18772333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.080382
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