Inhibition of the Lipopolysaccharide-Induced Stimulation of the Members of the MAPK Family in Human Monocytes/Macrophages by 4-Hydroxynonenal, a Product of Oxidized Omega-6 Fatty Acids

The compound 4-hydroxynonenal (4-HNE) is the major aldehyde formed during lipid peroxidation of ω-6-polyunsaturated fatty acids and has been suggested to regulate inflammatory responses because it inhibits tumor necrosis factor (TNF) mRNA production in the human monocytic cell line THP-1. Here we de...

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Main Authors: Marantos, Christos, Mukaro, Violet, Ferrante, Judith, Hii, Charles, Ferrante, Antonio
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2008
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Regular Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2543073/
https://ncbi.nlm.nih.gov/pubmed/18772336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.071150
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