Heme Oxygenase-1 Prevents Airway Mucus Hypersecretion Induced by Cigarette Smoke in Rodents and Humans

We investigated the role of heme oxygenase-1 (HO-1), a powerful anti-inflammatory and anti-oxidant enzyme, in modulating cigarette smoke (CS)-induced mucus secretion. In both rats and mice, 5-day CS exposure increased HO-1 expression and activity, mucus secretion, MUCIN 5AC (MUC5AC) gene and protein...

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Main Authors: Almolki, Abdelhamid, Guenegou, Armelle, Golda, Slawomir, Boyer, Laurent, Benallaoua, Mourad, Amara, Nadia, Bachoual, Rafik, Martin, Clémence, Rannou, François, Lanone, Sophie, Dulak, Jozef, Burgel, Pierre-Régis, El-Benna, Jamel, Leynaert, A. Benedicte, Aubier, Michel, Boczkowski, Jorge
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2008
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2543067/
https://ncbi.nlm.nih.gov/pubmed/18787101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070863
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