Bcl-x(L) induces Drp1-dependent synapse formation in cultured hippocampal neurons

Maturation of neuronal synapses is thought to involve mitochondria. Bcl-x(L) protein inhibits mitochondria-mediated apoptosis but may have other functions in healthy adult neurons in which Bcl-x(L) is abundant. Here, we report that overexpression of Bcl-x(L) postsynaptically increases frequency and...

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Hlavní autoři: Li, Hongmei, Chen, Yingbei, Jones, Adrienne F., Sanger, Richard H., Collis, Leon P., Flannery, Richard, McNay, Ewan C., Yu, Tingxi, Schwarzenbacher, Robert, Bossy, Blaise, Bossy-Wetzel, Ella, Bennett, Michael V. L., Pypaert, Marc, Hickman, John A., Smith, Peter J. S., Hardwick, J. Marie, Jonas, Elizabeth A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542873/
https://ncbi.nlm.nih.gov/pubmed/18250306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711647105
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