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Liver X receptor β (LXRβ): A link between β-sitosterol and amyotrophic lateral sclerosis–Parkinson's dementia

Administration of β-sitosterol (42 mg/kg per day) for 3 weeks to 8-month-old male LXRβ(−/−) mice resulted in the death of motor neurons in the lumbar region of the spinal cord and loss of tyrosine hydroxylase-positive dopaminergic neurons in the substantia nigra. In mice at 5 months of age, β-sitost...

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Autors principals: Kim, Hyun-Jin, Fan, Xiaotang, Gabbi, Chiara, Yakimchuk, Konstantin, Parini, Paolo, Warner, Margaret, Gustafsson, Jan-Åke
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542868/
https://ncbi.nlm.nih.gov/pubmed/18238900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711599105
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