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Contrasting Use of CCR5 Structural Determinants by R5 and R5X4 Variants within a Human Immunodeficiency Virus Type 1 Primary Isolate Quasispecies

Macrophagetropic R5 human immunodeficiency virus type 1 (HIV-1) isolates often evolve into dualtropic R5X4 variants during disease progression. The structural basis for CCR5 coreceptor function has been studied in a limited number of prototype strains and suggests that R5 and R5X4 Envs interact diff...

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Udgivet i:J Virol
Principais autores: Yi, Yanjie, Singh, Anjali, Shaheen, Farida, Louden, Andrew, Lee, ChuHee, Collman, Ronald G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC254272/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14581542/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.22.12057-12066.2003
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