Validation and extension of the PREMM(1,2) model in a population-based cohort of colorectal cancer patients

BACKGROUND AND AIMS: Early recognition of patients at risk for Lynch syndrome is critical but often difficult. Recently, a predictive algorithm -the PREMM(1,2) model- has been developed to quantify the risk of carrying a germline mutation in the mismatch repair (MMR) genes, MLH1 and MSH2. However, i...

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Autores principales: Balaguer, Francesc, Balmaña, Judith, Castellví-Bel, Sergi, Steyerberg, Ewout W., Andreu, Montserrat, Llor, Xavier, Jover, Rodrigo, Syngal, Sapna, Castells, Antoni
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542581/
https://ncbi.nlm.nih.gov/pubmed/18061181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2007.10.042
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