Airway Lipoxin A(4) Generation and Lipoxin A(4) Receptor Expression Are Decreased in Severe Asthma

Rationale: Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A(4) (LXA(4)) is an arachidonic acid–derived mediator that serves as an agonist for resolution of inflammation. Objectives: Airway levels of LXA(4), as well as the expression of l...

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Bibliographic Details
Main Authors: Planagumà, Anna, Kazani, Shamsah, Marigowda, Gautham, Haworth, Oliver, Mariani, Thomas J., Israel, Elliot, Bleecker, Eugene R., Curran-Everett, Douglas, Erzurum, Serpil C., Calhoun, William J., Castro, Mario, Chung, Kian Fan, Gaston, Benjamin, Jarjour, Nizar N., Busse, William W., Wenzel, Sally E., Levy, Bruce D.
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2008
Subjects:
A. Asthma and Allergy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542432/
https://ncbi.nlm.nih.gov/pubmed/18583575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200801-061OC
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