IL4Rα Mutations Are Associated with Asthma Exacerbations and Mast Cell/IgE Expression

Background: Severe asthma has been associated with severe exacerbations, lower lung function and greater tissue inflammation. Previous studies have suggested that mutations in interleukin-4 receptor α (IL4Rα) are associated with lower lung function, higher IgE, and a gain in receptor function. Howev...

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Detalhes bibliográficos
Main Authors: Wenzel, Sally E., Balzar, Silvana, Ampleford, Elizabeth, Hawkins, Gregory A., Busse, William W., Calhoun, William J., Castro, Mario, Chung, K. Fan, Erzurum, Serpil, Gaston, Benjamin, Israel, Elliot, Teague, W. Gerald, Curran-Everett, Douglas, Meyers, Deborah A., Bleecker, Eugene R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2007
Assuntos:
B. Asthma and Allergy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899282/
https://ncbi.nlm.nih.gov/pubmed/17170387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200607-909OC
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