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Signal Peptide-Dependent Inhibition of MHC Class I Heavy Chain Translation by Rhesus Cytomegalovirus

The US2-11 region of human and rhesus cytomegalovirus encodes a conserved family of glycoproteins that inhibit MHC-I assembly with viral peptides, thus preventing cytotoxic T cell recognition. Since HCMV lacking US2-11 is no longer able to block assembly and transport of MHC-I, we examined whether t...

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Main Authors: Powers, Colin J., Früh, Klaus
格式: Artigo
語言:Inglês
出版: Public Library of Science 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542416/
https://ncbi.nlm.nih.gov/pubmed/18833297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000150
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