Genetic and biological analyses of a herpes simplex virus intertypic recombinant reduced specifically for neurovirulence.

RS6 is a herpes simplex virus intertypic recombinant derived from type 1 strain 17 syn+ and type 2 strain HG52. With a 50% lethal dose of about 10(5) PFU after intracerebral inoculation of mice, RS6 was approximately 100,000 times less neurovirulent than either of its wild-type parental viruses were...

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Publicado en:	J Virol
Autores principales:	Javier, R T, Thompson, R L, Stevens, J G
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1987
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC254206/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3033324/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.61.6.1978-1984.1987
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