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Inhibition of the tyrosine kinase activity of v-src, v-fgr, and v-yes gene products by a monoclonal antibody which binds both amino and carboxy peptide fragments of pp60v-src.

A monoclonal antibody, R2D2, raised to the src gene product of Rous sarcoma virus was found to inhibit the tyrosine protein kinase activity of pp60v-src in autophosphorylation reactions and in reactions involving exogenously added substrates, such as casein and histone. R2D2 also inhibited the enzym...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: McCarley, D J, Parsons, J T, Benjamin, D C, Parsons, S J
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1987
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC254200/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2437325/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.61.6.1927-1937.1987
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