Chloramphenicol Is a Potent Inhibitor of Cytochrome P450 Isoforms CYP2C19 and CYP3A4 in Human Liver Microsomes

The inhibitory effect of chloramphenicol on human cytochrome P450 (CYP) isoforms was evaluated with human liver microsomes and cDNA-expressed CYPs. Chloramphenicol had a potent inhibitory effect on CYP2C19-catalyzed S-mephytoin 4′-hydroxylation and CYP3A4-catalyzed midazolam 1-hydroxylation, with ap...

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Bibliografiska uppgifter
I publikationen:Antimicrob Agents Chemother
Huvudupphovsmän: Park, Ji-Young, Kim, Kyoung-Ah, Kim, Su-Lyun
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2003
Ämnen:
Pharmacology
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC253795/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14576103/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.11.3464-3469.2003
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