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Dysregulated human renin expression in transgenic mice carrying truncated genomic constructs: evidence supporting the presence of insulators at the renin locus

We previously generated transgenic mice carrying a large P1 artificial chromosome (PAC160) encompassing a 160-kb segment containing the human renin gene, two upstream genes, and one downstream gene. We also previously generated mutant PAC160 constructs lacking the distal enhancer and concluded it is...

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מידע ביבליוגרפי
Main Authors: Zhou, Xiyou, Weatherford, Eric T., Liu, Xuebo, Born, Ella, Keen, Henry L., Sigmund, Curt D.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Physiological Society 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2536869/
https://ncbi.nlm.nih.gov/pubmed/18632798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00384.2007
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