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Differential coupling of Arg- and Gly389 polymorphic forms of the β(1)-adrenergic receptor leads to pathogenic cardiac gene regulatory programs
The β(1)-adrenergic receptor (β(1)AR; ADRB1) polymorphism Arg389Gly is located in an intracellular loop and is associated with distinct human and mouse cardiovascular phenotypes. To test the hypothesis that β(1)-Arg389 and β(1)-Gly389 alleles could differentially couple to pathways beyond that of cl...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2536824/ https://ncbi.nlm.nih.gov/pubmed/18664629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.90225.2008 |
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