Differential coupling of Arg- and Gly389 polymorphic forms of the β(1)-adrenergic receptor leads to pathogenic cardiac gene regulatory programs

The β(1)-adrenergic receptor (β(1)AR; ADRB1) polymorphism Arg389Gly is located in an intracellular loop and is associated with distinct human and mouse cardiovascular phenotypes. To test the hypothesis that β(1)-Arg389 and β(1)-Gly389 alleles could differentially couple to pathways beyond that of cl...

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Hlavní autoři: Swift, Steven M., Gaume, Brigitte R., Small, Kersten M., Aronow, Bruce J., Liggett, Stephen B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2008
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2536824/
https://ncbi.nlm.nih.gov/pubmed/18664629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.90225.2008
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