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Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas

BACKGROUND: Glioblastoma is the most lethal primary malignant brain tumor. Although considerable progress has been made in the treatment of this aggressive tumor, the clinical outcome for patients remains poor. Histone deacetylases (HDACs) are recognized as promising targets for cancer treatment. In...

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Autori principali: Lucio-Eterovic, Agda KB, Cortez, Maria AA, Valera, Elvis T, Motta, Fabio JN, Queiroz, Rosane GP, Machado, Helio R, Carlotti, Carlos G, Neder, Luciano, Scrideli, Carlos A, Tone, Luiz G
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2536671/
https://ncbi.nlm.nih.gov/pubmed/18713462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-243
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