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Hepatitis C Virus JFH-1 Strain Infection in Chimpanzees Is Associated with Low Pathogenicity and Emergence of an Adaptive Mutation

The identification of the hepatitis C virus (HCV) strain JFH-1 enabled the successful development of infectious cell culture systems. Although this strain replicates efficiently and produces infectious virus in cell culture, the replication capacity and pathogenesis in vivo are still undefined. To a...

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Detalhes bibliográficos
Main Authors: Kato, Takanobu, Choi, Youkyung, Elmowalid, Gamal, Sapp, Ronda K., Barth, Heidi, Furusaka, Akihiro, Mishiro, Shunji, Wakita, Takaji, Krawczynski, Krzysztof, Liang, T. Jake
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2535917/
https://ncbi.nlm.nih.gov/pubmed/18712792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22422
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