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Concise Synthesis of Guanidine-Containing Heterocycles Using the Biginelli Reaction
Two general methods for the synthesis of 2-imino-5-carboxy-3,4-dihydropyrimidines were developed using the 3-component Biginelli reaction. The first method utilizes pyrazole carboxamidine, a β-ketoester, and an aldehyde in an initial Biginelli reaction. After Boc protection, these products undergo a...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2535792/ https://ncbi.nlm.nih.gov/pubmed/16995677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo061199m |
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