A Random Mutagenesis Approach to Isolate Dominant-Negative Yeast sec1 Mutants Reveals a Functional Role for Domain 3a in Yeast and Mammalian Sec1/Munc18 Proteins

SNAP receptor (SNARE) and Sec1/Munc18 (SM) proteins are required for all intracellular membrane fusion events. SNAREs are widely believed to drive the fusion process, but the function of SM proteins remains unclear. To shed light on this, we screened for dominant-negative mutants of yeast Sec1 by ra...

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Main Authors: Boyd, Alan, Ciufo, Leonora F., Barclay, Jeff W., Graham, Margaret E., Haynes, Lee P., Doherty, Mary K., Riesen, Michèle, Burgoyne, Robert D., Morgan, Alan
格式: Artigo
語言:Inglês
出版: Genetics Society of America 2008
主題:
Investigations
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2535671/
https://ncbi.nlm.nih.gov/pubmed/18757920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.090423
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