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Genetic Analysis of the Role of Protein Kinase Cθ in Platelet Function and Thrombus Formation
BACKGROUND: PKCθ is a novel protein kinase C isozyme, predominately expressed in T cells and platelets. PKCθ(−/−) T cells exhibit reduced activation and PKCθ(−/−) mice are resistant to autoimmune disease, making PKCθ an attractive therapeutic target for immune modulation. Collagen is a major agonist...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2533697/ https://ncbi.nlm.nih.gov/pubmed/18815612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003277 |
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