Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57(KIP2 )and Cdk2

BACKGROUND: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the formation of multiple fluid-filled cysts that destroy the kidney architecture resulting in end-stage renal failure. Mutations in genes PKD1 and PKD2 account for nearly all cases of ADPKD. Increased cell prolifer...

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Main Authors: Felekkis, Kyriacos N, Koupepidou, Panayiota, Kastanos, Evdokia, Witzgall, Ralph, Bai, Chang-Xi, Li, Li, Tsiokas, Leonidas, Gretz, Norbert, Deltas, Constantinos
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533650/
https://ncbi.nlm.nih.gov/pubmed/18721488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2369-9-10
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