Novel Polymyxin Derivatives Carrying Only Three Positive Charges Are Effective Antibacterial Agents

The lack of novel antibiotics against gram-negative bacteria has reinstated polymyxins as the drugs of last resort to treat serious infections caused by extremely multiresistant gram-negative organisms. However, polymyxins are nephrotoxic, and this feature may complicate therapy or even require its...

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Main Authors: Vaara, Martti, Fox, John, Loidl, Günther, Siikanen, Osmo, Apajalahti, Juha, Hansen, Frank, Frimodt-Møller, Niels, Nagai, Junya, Takano, Mikihisa, Vaara, Timo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Mechanisms of Action: Physiological Effects
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533495/
https://ncbi.nlm.nih.gov/pubmed/18591267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00405-08
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