Pharmacokinetics of High-Dose Lopinavir-Ritonavir with and without Saquinavir or Nonnucleoside Reverse Transcriptase Inhibitors in Human Immunodeficiency Virus-Infected Pediatric and Adolescent Patients Previously Treated with Protease Inhibitors

Human immunodeficiency virus (HIV)-infected children and adolescents who are failing antiretrovirals may have a better virologic response when drug exposures are increased, using higher protease inhibitor doses or ritonavir boosting. We studied the pharmacokinetics and safety of high-dose lopinavir-...

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Detalhes bibliográficos
Main Authors: Robbins, Brian L., Capparelli, Edmund V., Chadwick, Ellen G., Yogev, Ram, Serchuck, Leslie, Worrell, Carol, Smith, Mary Elizabeth, Alvero, Carmelita, Fenton, Terence, Heckman, Barbara, Pelton, Stephen I., Aldrovandi, Grace, Borkowsky, William, Rodman, John, Havens, Peter L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533475/
https://ncbi.nlm.nih.gov/pubmed/18625762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00224-08
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