Pharmacokinetics of High-Dose Lopinavir-Ritonavir with and without Saquinavir or Nonnucleoside Reverse Transcriptase Inhibitors in Human Immunodeficiency Virus-Infected Pediatric and Adolescent Patients Previously Treated with Protease Inhibitors

Human immunodeficiency virus (HIV)-infected children and adolescents who are failing antiretrovirals may have a better virologic response when drug exposures are increased, using higher protease inhibitor doses or ritonavir boosting. We studied the pharmacokinetics and safety of high-dose lopinavir-...

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Bibliographic Details
Main Authors: Robbins, Brian L., Capparelli, Edmund V., Chadwick, Ellen G., Yogev, Ram, Serchuck, Leslie, Worrell, Carol, Smith, Mary Elizabeth, Alvero, Carmelita, Fenton, Terence, Heckman, Barbara, Pelton, Stephen I., Aldrovandi, Grace, Borkowsky, William, Rodman, John, Havens, Peter L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Clinical Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533475/
https://ncbi.nlm.nih.gov/pubmed/18625762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00224-08
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