Mutations in the fks1 Gene in Candida albicans, C. tropicalis, and C. krusei Correlate with Elevated Caspofungin MICs Uncovered in AM3 Medium Using the Method of the European Committee on Antibiotic Susceptibility Testing

Mutations in two specific regions of the Fks1 subunit of 1,3-β-d-glucan synthase are known to confer decreased caspofungin susceptibility on Candida spp. Clinical isolates of Candida spp. (404 Candida albicans, 62 C. tropicalis, and 21 C. krusei isolates) sent to the French National Reference Center...

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Detalhes bibliográficos
Main Authors: Desnos-Ollivier, Marie, Bretagne, Stéphane, Raoux, Dorothée, Hoinard, Damien, Dromer, Françoise, Dannaoui, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533459/
https://ncbi.nlm.nih.gov/pubmed/18591282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00088-08
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