Functional stoichiometry of the unitary calcium-release-activated calcium channel

Two proteins, STIM1 in the endoplasmic reticulum and Orai1 in the plasma membrane, are required for the activation of Ca(2+) release-activated Ca(2+) (CRAC) channels at the cell surface. How these proteins interact to assemble functional CRAC channels has remained uncertain. Here, we determine how m...

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Bibliografiske detaljer
Main Authors: Ji, Wei, Xu, Pingyong, Li, Zhengzheng, Lu, Jingze, Liu, Lin, Zhan, Yi, Chen, Yu, Hille, Bertil, Xu, Tao, Chen, Liangyi
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533247/
https://ncbi.nlm.nih.gov/pubmed/18757751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806499105
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